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Lanthanide scale-up phasing compounds (ref.: CSM002-0101A to CSM002-0110A)

Lanthanide derivatives are obtained with these compounds, either by soaking or by co-crystallization, into crystals of biological macromolecules. The crystal derivatives thus obtained can be used to solve the structure of biological macromolecules by using structure-determination methods taking advantage of the strong anomalous signal of lanthanides in their LIII absorption edge or, for some of them, with radiation from a lab X-ray source. Derivative based on Eu atom (LIII abs. edge: 6977 eV) or Yb atom (LIII abs. edge: 8944 eV) are available.

We propose these compounds individually in larger quantity than in the phasing kit, for the refinement of a promising derivative.

reference compound amount (mL) concentration (mM)
CSM002-0101A Eu-(DPA)3 1.0 200
CSM002-0102A Yb-(DPA)3 1.0 200
CSM002-0103A Eu-DOTA 0.2 500
CSM002-0104A Yb-DOTA 0.2 500
CSM002-0105A Eu-DO3A 0.2 500
CSM002-0106A Yb-DO3A 0.2 500
CSM002-0107A Eu-HPDO3A 0.2 500
CSM002-0108A Yb-HPDO3A 0.2 500
CSM002-0109A Eu-DTPA-BMA 0.2 500
CSM002-0110A Yb-DTPA-BMA 0.2 500

Full documentation is available here.

The structure of these compounds is available on the phasing kit page.

A list of publications related to the use of these complexes is available here.

Authors publishing results thanks to these compounds are welcome to cite the following papers:
For tris(dipicolinate)-lanthanide complexes:
Pompidor G, D'Aleo A, Vicat J, Toupet L, Giraud N, Kahn R, Maury O, Angew Chem Int Ed Engl. 47 (2008), 3388-3391
For the other complexes:
Girard E, Stelter M, Vicat J, Kahn R, Acta Cryst. D59 (2003), 1914-1922

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