Derivatives are obtained, either by soaking or by
co-crystallization, into crystals of biological macromolecules.
The crystal derivatives thus obtained can be used to solve the
structure of biological macromolecules by using structure-determination
methods taking advantage of the strong anomalous signal of lanthanides
in its LIII absorption edge or with radiation
from a lab X-ray source.
Full documentation is available here.
A list of publications related to the use of these complexes is available here.
Information on Gd-HPDO3A molecule:
Authors publishing results thanks to these compounds are welcome
to cite the following paper:
Girard E, Stelter M, Vicat J, Kahn R,
Acta Cryst. D59 (2003), 1914-1922